Postlethwaite J C
Ann R Coll Surg Engl. 1976 Nov;58(6):457-64.
The plasma fibrinogen concentration is directly related to blood viscosity, which in turn is inversely related to blood flow. The way in which the plasma fibrinogen level affects the clinical status of patients with peripheral vascular disease is discussed with reference to both retrospective and prospective studies of patients undergoing major arterial surgery. Animal experiments are described in which the effect of reducing the plasma fibrinogen level with oral clofibrate and parenteral Arvin (ancrod) on the patency of Dacron arterial grafts was studied.
血浆纤维蛋白原浓度与血液粘度直接相关，而血液粘度又与血流呈负相关。参照对接受主要动脉手术患者的回顾性和前瞻性研究，探讨了血浆纤维蛋白原水平影响外周血管疾病患者临床状况的方式。描述了动物实验，其中研究了口服氯贝丁酯和肠外给予安克洛酶（抗栓酶）降低血浆纤维蛋白原水平对涤纶动脉移植物通畅性的影响。
