Mahir M S, Hynd J W, Flute P T, Dormandy J A
Br J Surg. 1987 Jun;74(6):508-10. doi: 10.1002/bjs.1800740630.
The effect of defibrinogenation with Arvin was studied in a new animal model of early thrombosis of a 3 mm diameter polytetrafluoroethylene (PTFE) graft with a poor run-off. Fifteen control animals were compared with fourteen animals treated with subcutaneous Arvin 20 units kg-1 body weight day-1, starting 2 days before surgery and continuing for 2 days postoperatively. The peroperative fibrinogen level in the controls was 2.8 +/- 0.9 gl-1 compared with 0.4 +/- 0.3 gl-1 in the treated group. There was no significant difference in the peroperative or postoperative platelet count or haematocrit value between the two groups. Plasma viscosity and whole blood viscosity (at a low shear rate of 0.7s-1) were significantly less during and after surgery in the defibrinogenated group. The degree of defibrinogenation in these animals produced no problems with haemostasis during surgery or in the postoperative period. The cumulative patency rates of the controls at 24 h, 48 h, and 4 days were 43 per cent, 28 per cent and 28 per cent compared with 86 per cent (P less than 0.05), 73 per cent (P less than 0.05) and 73 per cent (P less than 0.05) respectively in the defibrinogenated group. In this model of a narrow PTFE graft with a poor run-off, defibrinogenation was a safe and effective method of improving early patency of small calibre arterial grafts.
在一种新的动物模型中，研究了用蝮蛇抗栓酶去纤维蛋白原对直径3毫米且流出道较差的聚四氟乙烯（PTFE）移植物早期血栓形成的影响。将15只对照动物与14只接受皮下注射蝮蛇抗栓酶（20单位/千克体重/天）的动物进行比较，从手术前2天开始，术后持续2天。对照组术中纤维蛋白原水平为2.8±0.9克/升，而治疗组为0.4±0.3克/升。两组术中或术后血小板计数或血细胞比容值无显著差异。去纤维蛋白原组在手术期间和术后血浆粘度和全血粘度（低剪切率0.7秒-1时）显著降低。这些动物的去纤维蛋白原程度在手术期间或术后并未导致止血问题。对照组在24小时、48小时和4天时的累积通畅率分别为43%、28%和28%，而去纤维蛋白原组分别为86%（P<0.05）、73%（P<0.05）和73%（P<0.05）。在这种流出道较差的狭窄PTFE移植物模型中，去纤维蛋白原是提高小口径动脉移植物早期通畅率的一种安全有效的方法。
