PIR国际蛋白质序列数据库。

The PIR-International Protein Sequence Database.

作者信息

Barker W C, Garavelli J S, McGarvey P B, Marzec C R, Orcutt B C, Srinivasarao G Y, Yeh L S, Ledley R S, Mewes H W, Pfeiffer F, Tsugita A, Wu C

机构信息

Protein Information Resource, National Biomedical Research Foundation, Washington, DC 20007, USA, USA.

出版信息

Nucleic Acids Res. 1999 Jan 1;27(1):39-43. doi: 10.1093/nar/27.1.39.

DOI:10.1093/nar/27.1.39

PMID:9847137

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC148092/

Abstract

The Protein Information Resource (PIR; http://www-nbrf.georgetown. edu/pir/) supports research on molecular evolution, functional genomics, and computational biology by maintaining a comprehensive, non-redundant, well-organized and freely available protein sequence database. Since 1988 the database has been maintained collaboratively by PIR-International, an international association of data collection centers cooperating to develop this resource during a period of explosive growth in new sequence data and new computer technologies. The PIR Protein Sequence Database entries are classified into superfamilies, families and homology domains, for which sequence alignments are available. Full-scale family classification supports comparative genomics research, aids sequence annotation, assists database organization and improves database integrity. The PIR WWW server supports direct on-line sequence similarity searches, information retrieval, and knowledge discovery by providing the Protein Sequence Database and other supplementary databases. Sequence entries are extensively cross-referenced and hypertext-linked to major nucleic acid, literature, genome, structure, sequence alignment and family databases. The weekly release of the Protein Sequence Database can be accessed through the PIR Web site. The quarterly release of the database is freely available from our anonymous FTP server and is also available on CD-ROM with the accompanying ATLAS database search program.

摘要

蛋白质信息资源库（PIR；http://www-nbrf.georgetown.edu/pir/）通过维护一个全面、非冗余、组织良好且免费可用的蛋白质序列数据库，来支持分子进化、功能基因组学和计算生物学方面的研究。自1988年以来，该数据库由国际蛋白质信息资源库（PIR-International）合作维护，PIR-International是一个数据收集中心的国际协会，在新序列数据和新计算机技术呈爆炸式增长的时期共同开发了这一资源。PIR蛋白质序列数据库条目被分类为超家族、家族和同源结构域，并提供了相应的序列比对。全面的家族分类支持比较基因组学研究，有助于序列注释，辅助数据库组织并提高数据库完整性。PIR万维网服务器通过提供蛋白质序列数据库和其他补充数据库，支持直接的在线序列相似性搜索、信息检索和知识发现。序列条目与主要的核酸、文献、基因组、结构、序列比对和家族数据库进行了广泛的交叉引用和超文本链接。蛋白质序列数据库的每周更新版本可通过PIR网站访问。该数据库的季度更新版本可从我们的匿名FTP服务器免费获取，也可随附ATLAS数据库搜索程序以光盘形式获得。