RegulonDB（版本2.0）：一个关于大肠杆菌转录调控的数据库。

RegulonDB (version 2.0): a database on transcriptional regulation in Escherichia coli.

作者信息

Salgado H, Santos A, Garza-Ramos U, van Helden J, Díaz E, Collado-Vides J

机构信息

Centro de Investigación sobre Fijación de Nitrógeno, UNAM A.P., 565-A Cuernavaca, Morelos 62100, México.

出版信息

Nucleic Acids Res. 1999 Jan 1;27(1):59-60. doi: 10.1093/nar/27.1.59.

DOI:10.1093/nar/27.1.59

PMID:9847141

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC148096/

Abstract

RegulonDB version 2.0, a database on transcriptional regulation and operon organization in Escherichia coli, is now available on the web at the following URL: http://www.cifn.unam. mx/Computational_Biology/regulondb/. In this paper we describe the main computational changes to the database, which include migrating the database to Sybase, providing graphical descriptions of the internal organization of operons and regulons, and direct links to MEDLINE references. The web interface offers searching either by mechanisms of regulation or by operon organization. The results of a search (operon organization, or site collection) are displayed as hypertext, and can also be displayed graphically. In terms of its contents, RegulonDB contains a large number of operons, as well as the absolute position in the completed genome sequence of sites, promoters, and individual genes of E.coli.

摘要

RegulonDB 2.0版，一个关于大肠杆菌转录调控和操纵子组织的数据库，现已在以下网址上线：http://www.cifn.unam. mx/Computational_Biology/regulondb/。在本文中，我们描述了该数据库的主要计算方面的变化，包括将数据库迁移到Sybase，提供操纵子和调控子内部组织的图形描述，以及与MEDLINE参考文献的直接链接。网络界面提供按调控机制或操纵子组织进行搜索。搜索结果（操纵子组织或位点集合）以超文本形式显示，也可以图形方式显示。就其内容而言，RegulonDB包含大量操纵子，以及大肠杆菌位点、启动子和单个基因在完整基因组序列中的绝对位置。

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