Holmes A L, Heilig J S
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309-0347, USA.
Development. 1999 Jan;126(2):261-72. doi: 10.1242/dev.126.2.261.
Previous studies demonstrated that Fasciclin II and Beaten path are necessary for regulating cell adhesion events that are important for motoneuron development in Drosophila. We observe that the cell adhesion molecule Fasciclin II and the secreted anti-adhesion molecule Beaten path have additional critical roles in the development of at least one set of sensory organs, the larval visual organs. Taken together, phenotypic analysis, genetic interactions, expression studies and rescue experiments suggest that, in normal development, secretion of Beaten path by cells of the optic lobes allows the Fasciclin II-expressing larval visual organ cells to detach from the optic lobes as a cohesive cell cluster. Our results also demonstrate that mechanisms guiding neuronal development may be shared between motoneurons and sensory organs, and provide evidence that titration of adhesion and anti-adhesion is critical for early steps in development of the larval visual system.
先前的研究表明，成束蛋白II和Beat通路对于调节细胞黏附事件是必需的，而这些事件对于果蝇运动神经元的发育很重要。我们观察到，细胞黏附分子成束蛋白II和分泌型抗黏附分子Beat通路在至少一组感觉器官即幼虫视觉器官的发育中具有额外的关键作用。综合来看，表型分析、遗传相互作用、表达研究和拯救实验表明，在正常发育过程中，视叶细胞分泌的Beat通路使表达成束蛋白II的幼虫视觉器官细胞作为一个紧密的细胞簇从视叶分离。我们的结果还表明，指导神经元发育的机制可能在运动神经元和感觉器官之间是共享的，并提供了证据表明黏附和抗黏附的平衡对于幼虫视觉系统发育的早期步骤至关重要。
