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[婴幼儿期和儿童期的门德尔松综合征]

[Mendelson syndrome in infancy and childhood].

作者信息

Baum W F, Klöditz E, Nagel F, Gröger K, Sitka U

机构信息

Klinik und Poliklinik für Kinderheilkunde der Martin-Luther-Universität Halle-Wittenberg.

出版信息

Pneumologie. 1998 Oct;52(10):556-9.

PMID:9847633
Abstract

Acute pulmonary failure caused by gastric acid aspiration is designated as Mendelson's syndrome. It is characterized by a trias of symptoms comprising bronchial obstruction, pulmonary oedema, and right ventricular failure. The pathomorphological pulmonary alterations show the typical symptoms of ARDS and allow the differentiation of three phases. The initial phase of injury is characterized by cauterization of the bronchial and alveolar epithelium. It is followed by the exsudative second phase during which alveolar oedema are developing. They impair the pulmonary surfactant synthesis and the formation of hyaline membranes. Fibrosis processes are typical of the proliferative third phase. Every of the mentioned three phases may be classified by their corresponding clinical symptoms. The therapy is entirely symptomatic and follows the intensive medical standards of the ARDS-therapy.

摘要

由胃酸误吸引起的急性肺衰竭被称为门德尔松综合征。其特征是由支气管阻塞、肺水肿和右心室衰竭组成的三联征症状。病理形态学上的肺部改变表现出急性呼吸窘迫综合征(ARDS)的典型症状,并可区分三个阶段。损伤的初始阶段以支气管和肺泡上皮的烧灼为特征。随后是渗出性的第二阶段,在此期间肺泡水肿逐渐形成。它们损害肺表面活性物质的合成和透明膜的形成。纤维化过程是增生性第三阶段的典型特征。上述三个阶段中的每一个阶段都可以根据其相应的临床症状进行分类。治疗完全是对症治疗,并遵循ARDS治疗的强化医疗标准。

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