Sundmacher R, Reinhard T
Augenklinik der Heinrich-Heine-Universität, Düsseldorf.
Klin Monbl Augenheilkd. 1998 Oct;213(4):254-5. doi: 10.1055/s-2008-1034984.
It is the purpose of this case report to present a new surgical technique for treatment of severe limbal stem cell deficiency.
In a 42-year-old female patient with conjunctivalization of the cornea in congenital aniridia a homologous lamellar central limbokeratoplasty was performed. Postoperatively systemic Ciclosporin A was administered in order to prevent the transplanted limbal stem cells from immunological destruction. During the follow-up period of 16 months no immune reaction against the transplanted limbal stem cells could be observed. Visual acuity was ameliorated considerably.
Homologous lamellar central limbokeratoplasty is a promising surgical procedure in selected patients with severe limbal stem cell deficiency having less complications compared with penetrating central limbokeratoplasty.
本病例报告旨在介绍一种治疗严重角膜缘干细胞缺乏的新手术技术。
对一名42岁患有先天性无虹膜角膜结膜化的女性患者进行了同种异体板层中央角膜缘移植术。术后给予全身环孢素A以防止移植的角膜缘干细胞受到免疫破坏。在16个月的随访期内，未观察到针对移植角膜缘干细胞的免疫反应。视力有显著改善。
同种异体板层中央角膜缘移植术对于选定的严重角膜缘干细胞缺乏患者是一种有前景的手术方法，与穿透性中央角膜缘移植术相比并发症更少。
