[视黄醇在体外向细胞核的转运]
[Retinol transport into the cell nucleus in vitro].
作者信息
Chetyrkin S V, Chernukhina L A, Donchenko G V
机构信息
A.V. Palladin Institute of Biochemistry, Kiev.
出版信息
Ukr Biokhim Zh (1978). 1998 Mar-Apr;70(2):15-21.
The retinol interaction with intact cellular nuclei, nuclear envelope and chromatin was investigated. We have shown that the Cellular Retinol-Binding Protein (CRBP) plays a very important role in such interaction. Retinol can specifically interacts with nuclei, nuclear envelope and chromatin only when it presents as a complex with CRBP. The obtained data allowed us to suggest that the process of retinol delivery to hypothetical nuclear receptors include of at least the following stages: 1) specific binding with nuclear envelope; 2) penetration into nuclei; 3) specific binding with chromatin receptors. CRBP is a necessary component at all this stages. Also we show that CRBP has not a species or tissue specificity.
研究了视黄醇与完整细胞核、核膜和染色质的相互作用。我们已经表明，细胞视黄醇结合蛋白（CRBP）在这种相互作用中起着非常重要的作用。视黄醇只有在与CRBP形成复合物时才能特异性地与细胞核、核膜和染色质相互作用。所获得的数据使我们能够推测，视黄醇传递到假设的核受体的过程至少包括以下阶段：1）与核膜特异性结合；2）渗透到细胞核中；3）与染色质受体特异性结合。CRBP在所有这些阶段都是必需的成分。我们还表明，CRBP没有物种或组织特异性。
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