Hula N M, Marhitych V M, Hovseieva N M, Klimashevs'kyĭ V M, Zhukov O D, Synyts'kyĭ V M
O.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine.
Ukr Biokhim Zh (1978). 1998 Mar-Apr;70(2):98-105.
The brain phospholipid content was studied in rats with morphine physical dependence. It was found that level of total lipids, total phospholipids and cholesterol was diminished. The significant decrease of absolute amounts of phosphotidyl serine, phosphotidyl inositol, sphingomyelin and phosphatidyl choline was shown. At the same time the percent relation of individual phospholipids did not change. As the exclusion, the quantity of phosphatidyl ethanolamine plasmalogen lowered in rats with morphine dependence. The percent content of fatty acids 16:0, 18:1 omega 9, 20:1 omega 11, 20:4 omega 6 and 22:5 omega 3 was found to be reduced. At the same time the percent amount of i18:0 and 20:0 was shown to increase. As a result the unsaturation index dramatically diminished. It was also shown that under morphine physical dependence the acyl residues of phosphatidyl choline and phosphatidyl ethanolamine changed. It was concluded that lipids play significant role in the development of morphine physical dependence.
对吗啡身体依赖的大鼠的脑磷脂含量进行了研究。发现总脂质、总磷脂和胆固醇水平降低。显示磷脂酰丝氨酸、磷脂酰肌醇、鞘磷脂和磷脂酰胆碱的绝对量显著下降。同时，各个磷脂的百分比关系没有变化。作为例外，吗啡依赖大鼠中缩醛磷脂酰乙醇胺的量降低。发现脂肪酸16:0、18:1 ω9、20:1 ω11、20:4 ω6和22:5 ω3的百分比含量降低。同时，i18:0和20:0的百分比含量增加。结果，不饱和度指数显著降低。还表明，在吗啡身体依赖状态下，磷脂酰胆碱和磷脂酰乙醇胺的酰基残基发生了变化。得出结论，脂质在吗啡身体依赖的发展中起重要作用。
