Nizhenkovskaia I V, Gubskiĭ Iu I, Checkman I S, Goriushko A G, Gorchakova N A, Sachenko L G
National Medical University, Kyiv.
Ukr Biokhim Zh (1978). 1998 Jul-Aug;70(4):51-8.
Antiradical activity and ability to interaction with phosphatidylcholine bilayer of the physiological active compounds (PhAC), concerning the classes of phenylalkilamines (dobutamine, verapamil), dihydro pyridines (BAY-K-4688, nifedipine), analogues of crown ether (carbicyle, diol) was studied. By means of the method of microcalorimetry and spectrophotometry it was shown the complexing ability PhAC with the phospholipid bilayer of the model membrane. It was stated the simbasity in the changes of the thermal effect of the compounds with the negative inotropic activity during its reaction with phosphatidylcholine bilayer and antiradical activity. That show on the presence of antiradical component in the mechanism that compounds' action.
研究了生理活性化合物（PhAC）中苯烷基胺类（多巴酚丁胺、维拉帕米）、二氢吡啶类（BAY-K-4688、硝苯地平）、冠醚类似物（碳环、二醇）的抗自由基活性及其与磷脂酰胆碱双层相互作用的能力。通过微量量热法和分光光度法表明了PhAC与模型膜磷脂双层的络合能力。结果表明，具有负性肌力活性的化合物在与磷脂酰胆碱双层反应过程中的热效应变化与抗自由基活性具有相似性。这表明化合物作用机制中存在抗自由基成分。
