Prokopenko P A, Mogilevich S E, Batrak G N, Luĭk A I
Institute of Bioorganic Chemistry and Oil Chemistry NAS Ukraine, Kyiv.
Ukr Biokhim Zh (1978). 1998 Jul-Aug;70(4):101-5.
The influence of the tricyclic antidepressants imipramine and ftoracizin on platelet aggregation and smooth muscle contractility was investigated in comparison with action of known smooth muscle relaxant and platelet aggregation inhibitor, papaverine. It has been shown that the tricyclic antidepressants possess potent spasmolytic activity but unlike papaverine have no effect on platelet aggregation. The biochemical mechanisms of the non-specific action of tricyclic antidepressants as well as some other structurally related-drugs are discussed.
将三环类抗抑郁药丙咪嗪和氟拉嗪与已知的平滑肌松弛剂和血小板聚集抑制剂罂粟碱的作用相比较，研究了它们对血小板聚集和平滑肌收缩性的影响。结果表明，三环类抗抑郁药具有强大的解痉活性，但与罂粟碱不同，它们对血小板聚集没有影响。本文还讨论了三环类抗抑郁药以及其他一些结构相关药物非特异性作用的生化机制。
