[Effect of blocking the neuronal and extraneuronal uptake of bioamines on the adrenosensitizing action of tricyclic antidepressants].

Tests conducted on isolated and denervated preparations of the rat seminal duct brought evidence that tricyclic antidepressants (melipromine, noverile and azaphen) when employed in low concentrations (1-10(-9) g/ml) produced an adrenosensitizing effect. Denervation with the subsequent block by desoxycorticosterone (1-10(-5) g/ml) of exteraneuronal amine uptake did not alter the position, shape and inclination of the "concentration-effect" noradrenaline curves received in the presence of noverile and cocaine. It is believed that there exists a predominance of the postsynaptic mechanism of the aminosensitizing action of tricyclic antidepressants on the smooth muscle organ.