Johnson A P, Warner M, Speller D C
Laboratory of Hospital Infection, Central Public Health Laboratory, Colindale, London, UK.
J Antimicrob Chemother. 1998 Nov;42(5):643-6. doi: 10.1093/jac/42.5.643.
The activity of sanfetrinem (previously GV104326), was assessed against 168 isolates of Streptococcus pneumoniae and 90 isolates of Staphylococcus aureus. These isolates included a range of serotypes or phage types, and varied in their susceptibility to other antibiotics. Sanfetrinem exhibited good anti-pneumococcal activity, with MIC90s of < or = 0.007 mg/L and 0.5 mg/L for penicillin-susceptible and penicillin-resistant isolates, respectively. Sanfetrinem was also active against methicillin-susceptible staphylococci (MIC90 = 0.06 mg/L). However, the MICs of sanfetrinem for isolates with methicillin MICs of 8-16 mg/L and > or = 32 mg/L were 0.25-1 mg/L and 8->32 mg/L, respectively.
对168株肺炎链球菌和90株金黄色葡萄球菌评估了sanfetrinem（以前称为GV104326）的活性。这些分离株包括一系列血清型或噬菌体类型，并且对其他抗生素的敏感性各不相同。Sanfetrinem表现出良好的抗肺炎球菌活性，对青霉素敏感和青霉素耐药分离株的MIC90分别≤0.007mg/L和0.5mg/L。Sanfetrinem对甲氧西林敏感葡萄球菌也有活性（MIC90 = 0.06mg/L）。然而，对于甲氧西林MIC为8 - 16mg/L和≥32mg/L的分离株，sanfetrinem的MIC分别为0.25 - 1mg/L和8->32mg/L。
