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L-695,256（一种对耐甲氧西林葡萄球菌有效的碳青霉烯类药物）的抗菌活性比较

Comparative antibacterial activity of L-695,256, a carbapenem active against methicillin-resistant staphylococci.

作者信息

Rylander M, Rollof J, Jacobsson K, Norrby S R

机构信息

Department of Clinical Microbiology, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.

出版信息

Antimicrob Agents Chemother. 1995 May;39(5):1178-81. doi: 10.1128/AAC.39.5.1178.

DOI:10.1128/AAC.39.5.1178
PMID:7625810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162705/
Abstract

The activity of a new prototype carbapenem, L-695,256, against clinical isolates of gram-positive and gram-negative aerobes was studied in vitro by agar dilution. L-695,256 was highly active against methicillin-resistant and -susceptible isolates of staphylococci (MICs, 0.016 to 2 micrograms/ml) and against penicillin-resistant pneumococci (MICs, 0.016 to 0.064 micrograms/ml), irrespective of penicillin susceptibility. Activity against members of the family Enterobacteriaceae was less than that of imipenem, while Proteus mirabilis and Morganella morganii were more susceptible to L-695,256.

摘要

采用琼脂稀释法在体外研究了新型碳青霉烯类原型药物L-695,256对革兰氏阳性和革兰氏阴性需氧菌临床分离株的活性。L-695,256对耐甲氧西林和甲氧西林敏感的葡萄球菌分离株（MICs为0.016至2微克/毫升）以及对耐青霉素肺炎球菌（MICs为0.016至0.064微克/毫升）具有高度活性，与青霉素敏感性无关。对肠杆菌科成员的活性低于亚胺培南，而奇异变形杆菌和摩根氏摩根菌对L-695,256更敏感。

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本文引用的文献

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In vitro susceptibility of methicillin-resistant Staphylococcus aureus to imipenem and other antimicrobial agents.耐甲氧西林金黄色葡萄球菌对亚胺培南及其他抗菌药物的体外敏感性
Chemioterapia. 1987 Aug;6(4):261-3.
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J Antimicrob Chemother. 1989 Mar;23 Suppl C:59-64. doi: 10.1093/jac/23.suppl_c.59.