L-695,256（一种对耐甲氧西林葡萄球菌有效的碳青霉烯类药物）的抗菌活性比较
Comparative antibacterial activity of L-695,256, a carbapenem active against methicillin-resistant staphylococci.
作者信息
Rylander M, Rollof J, Jacobsson K, Norrby S R
机构信息
Department of Clinical Microbiology, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
出版信息
Antimicrob Agents Chemother. 1995 May;39(5):1178-81. doi: 10.1128/AAC.39.5.1178.
Abstract
The activity of a new prototype carbapenem, L-695,256, against clinical isolates of gram-positive and gram-negative aerobes was studied in vitro by agar dilution. L-695,256 was highly active against methicillin-resistant and -susceptible isolates of staphylococci (MICs, 0.016 to 2 micrograms/ml) and against penicillin-resistant pneumococci (MICs, 0.016 to 0.064 micrograms/ml), irrespective of penicillin susceptibility. Activity against members of the family Enterobacteriaceae was less than that of imipenem, while Proteus mirabilis and Morganella morganii were more susceptible to L-695,256.
摘要
采用琼脂稀释法在体外研究了新型碳青霉烯类原型药物L-695,256对革兰氏阳性和革兰氏阴性需氧菌临床分离株的活性。L-695,256对耐甲氧西林和甲氧西林敏感的葡萄球菌分离株（MICs为0.016至2微克/毫升）以及对耐青霉素肺炎球菌（MICs为0.016至0.064微克/毫升）具有高度活性，与青霉素敏感性无关。对肠杆菌科成员的活性低于亚胺培南，而奇异变形杆菌和摩根氏摩根菌对L-695,256更敏感。
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