Güler N, Ones U, Somer A, Salman N, Yalçin I
Department of Pediatrics, Istanbul University Faculty of Medicine, Turkey.
Int J Tuberc Lung Dis. 1998 Nov;2(11):885-90.
Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Turkey, between January 1984 and December 1996.
To explore whether neonatal BCG vaccination offers any protective effect on clinical and laboratory profiles of central nervous system (CNS) tuberculosis in children.
A retrospective review of cases of CNS tuberculosis diagnosed and treated in one institution.
Of the 145 patients identified with CNS tuberculosis, 9.6% were vaccinated during the neonatal period. The rate of close contact with contagious pulmonary tuberculosis in family, age distribution, clinical findings and laboratory investigations on admission were not significantly different in vaccinated and non-vaccinated children. Although mortality rate in the vaccinated patients (8.3%) was found to be nearly half of that in the non-vaccinated group (15.1%), severe sequelae were significantly more frequent (P < 0.02) among the vaccinated patients;
This study shows that neonatal BCG vaccine has little effect on the clinical findings of subsequent CNS tuberculosis, and that these children have typical presentations of tuberculosis disease.
1984年1月至1996年12月期间，土耳其伊斯坦布尔伊斯坦布尔大学医学院儿科学系。
探讨新生儿卡介苗接种对儿童中枢神经系统（CNS）结核病的临床和实验室特征是否具有任何保护作用。
对在一家机构诊断和治疗的CNS结核病病例进行回顾性研究。
在确诊为CNS结核病的145例患者中，9.6%在新生儿期接种了疫苗。接种疫苗和未接种疫苗的儿童在家庭中与传染性肺结核的密切接触率、年龄分布、临床症状以及入院时的实验室检查结果并无显著差异。虽然接种疫苗患者的死亡率（8.3%）约为未接种疫苗组（15.1%）的一半，但接种疫苗的患者出现严重后遗症的情况明显更为频繁（P<0.02）。
本研究表明，新生儿卡介苗接种对后续CNS结核病的临床表现影响不大，且这些儿童具有典型的结核病表现。
