Isolation and physicochemical characterisation of the DNA from normal human skin and psoriatic scales.

In psoriatic parakeratosis preserved nuclei are found in the epidermal horny layer. The question arises, whether the components of the nuclei remain unchanged. Thus we isolated and purified the DNA of psoriatic scales and normal skin. Comparing the melting points and circular dichroism of both DNAs no significant difference could be detected. These data indicate the same guanine-cytosine content as well as comparabel helical compositions of the isolated DNAs.