Ferriolli E, Oliveira R B, Matsuda N M, Braga F J, Dantas R O
Department of Internal Medicine, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
J Am Geriatr Soc. 1998 Dec;46(12):1534-7. doi: 10.1111/j.1532-5415.1998.tb01538.x.
To compare esophageal motility and gastroesophageal reflux characteristics in young, middle-aged, and older healthy volunteers.
Comparison of conventional esophageal manometry and scintigraphic study of gastroesophageal reflux in volunteers aged 20 to 30 years, 50 to 60 years, and 70 to 80 years.
Gastroenterology and nuclear medicine laboratories of a tertiary care university hospital.
Forty healthy adult volunteers recruited from the community, 20 aged 20 to 30 years, 10 aged 50 to 60 years, and 10 aged from 70 to 80 years.
Each volunteer underwent conventional esophageal manometry and scintigraphic study of gastroesophageal reflux. Contractile wave amplitude, duration, velocity, and lower esophageal sphincter relaxation duration, as well as the presence of abnormal peristalsis, were correlated with the proportion of volunteers with gastroesophageal reflux and the number and duration of gastroesophageal reflux episodes.
Quantitative manometric parameters showed no correlation with gastroesophageal reflux patterns. Abnormal peristalsis was found more frequently in the older volunteers. The number of gastroesophageal reflux episodes per volunteer was similar in the three age groups, but the duration of gastroesophageal reflux episodes was longer in the older volunteers.
Healthy older persons have impaired clearance of refluxed materials associated with a high incidence of defective esophageal peristalsis. This may explain the higher severity of reflux esophagitis in older people.
比较年轻、中年和老年健康志愿者的食管动力及胃食管反流特征。
对年龄在20至30岁、50至60岁以及70至80岁的志愿者进行传统食管测压和胃食管反流闪烁扫描研究，并进行比较。
一所三级护理大学医院的胃肠病学和核医学实验室。
从社区招募的40名健康成年志愿者，其中20名年龄在20至30岁，10名年龄在50至60岁，10名年龄在70至80岁。
每位志愿者均接受传统食管测压和胃食管反流闪烁扫描研究。将收缩波幅度、持续时间、速度、食管下括约肌松弛持续时间，以及异常蠕动的存在情况，与胃食管反流志愿者的比例、胃食管反流发作的次数和持续时间进行关联分析。
定量测压参数与胃食管反流模式无相关性。老年志愿者中异常蠕动的发现更为频繁。三个年龄组中每位志愿者的胃食管反流发作次数相似，但老年志愿者的胃食管反流发作持续时间更长。
健康老年人清除反流物质的能力受损，且食管蠕动功能缺陷的发生率较高。这可能解释了老年人反流性食管炎病情更严重的原因。
