21岁队列中的2型单纯疱疹病毒感染
Herpes simplex type 2 infection in a cohort aged 21 years.
作者信息
Eberhart-Phillips J, Dickson N P, Paul C, Fawcett J P, Holland D, Taylor J, Cunningham A L
机构信息
Department of Preventive and Social Medicine, University of Otago Medical School, Dunedin, New Zealand.
出版信息
Sex Transm Infect. 1998 Jun;74(3):216-8. doi: 10.1136/sti.74.3.216.
OBJECTIVES
To measure the prevalence of HSV-2 antibodies in a birth cohort of 21 year old New Zealanders from whom detailed sexual histories had been obtained, and to assess the potential for HSV-2 serology in characterising a young adult population's risk for sexually transmitted diseases (STD).
METHODS
Sera from 784 cohort members were tested using an indirect IgG enzyme linked immunoassay specific to the HSV-2 glycoprotein G. Positive results were confirmed by western blot.
RESULTS
In all, 27 subjects were seropositive for HSV-2 (3.4%), only seven of whom gave a history of genital herpes (26%). Risk among females increased with lifetime number of partners, while risk for males increased with having a first partner who was aged 16 years or under.
CONCLUSIONS
The seroprevalence of HSV-2 infection in this cohort was low, but similar to that seen in several other populations in this age group. HSV-2 seropositivity did not appear to be a sensitive marker for high risk sexual activity in this young population. This may be because a critical mass of HSV-2 carriers has not accumulated among potential partners by age 21 years.
目的
测定一组详细记录了性病史的21岁新西兰人群中单纯疱疹病毒2型（HSV-2）抗体的流行率，并评估HSV-2血清学在确定年轻成年人群体性传播疾病（STD）风险方面的潜力。
方法
使用针对HSV-2糖蛋白G的间接IgG酶联免疫吸附测定法检测784名队列成员的血清。阳性结果通过蛋白质印迹法确认。
结果
共有27名受试者HSV-2血清学呈阳性（3.4%），其中只有7人有生殖器疱疹病史（26%）。女性的风险随着终身性伴侣数量的增加而增加，而男性的风险随着首个性伴侣年龄在16岁及以下而增加。
结论
该队列中HSV-2感染的血清流行率较低，但与该年龄组其他一些人群的情况相似。在这个年轻人群体中，HSV-2血清学阳性似乎不是高风险性行为的敏感标志物。这可能是因为到21岁时，潜在性伴侣中尚未积累足够数量的HSV-2携带者。
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