Eberhart-Phillips J E, Dickson N P, Paul C, Herbison G P, Taylor J, Cunningham A L
Department of Preventive and Social Medicine, University of Otago Medical School, Dunedin, New Zealand.
Sex Transm Infect. 2001 Oct;77(5):353-7. doi: 10.1136/sti.77.5.353.
To examine changes in the incidence and prevalence of herpes simplex type 2 (HSV-2) infection in a birth cohort of 26 year old New Zealanders in whom seroprevalence had been measured at 3.4% at age 21.
Sera from 869 cohort members were tested using an indirect IgG enzyme linked immunoassay specific to the HSV-2 glycoprotein G. Serological results were compared with detailed sexual histories.
In all, 96 participants (11%) were seropositive for HSV-2, including at least 56 who seroconverted after their 21st birthday. Among those known to be seronegative at age 21, the annual seroconversion rate was 13.5 cases per 1000 per year, compared with 8.1 cases per 1000 per sexually active year before age 21. New infections were associated with female sex and an early age of first intercourse. The average rate of partner change was lower in the cohort after age 21, and was only modestly increased among those who acquired new HSV-2 infections between ages 21 and 26.
HSV-2 seroprevalence has risen sharply in this sexually active cohort, despite a reduction in the overall level of partner change. Increased rates of HSV-2 acquisition after age 21 may be due to a higher prevalence of infection in the pool of potential partners encountered during the third decade of life. Factors related to partner choice may have more influence on the risk of HSV-2 infection than the number of sexual partners alone.
在一个26岁的新西兰出生队列中，研究单纯疱疹病毒2型（HSV - 2）感染的发病率和患病率的变化，该队列在21岁时血清阳性率经测量为3.4%。
使用针对HSV - 2糖蛋白G的间接IgG酶联免疫测定法检测869名队列成员的血清。将血清学结果与详细的性病史进行比较。
共有96名参与者（11%）HSV - 2血清呈阳性，其中至少56人在21岁生日后血清阳转。在21岁时已知血清阴性的人群中，年血清阳转率为每1000人每年13.5例，而在21岁之前每性活跃年为每1000人8.1例。新感染与女性性别和初次性交年龄早有关。21岁之后该队列中伴侣更换的平均率较低，在21岁至26岁之间获得新的HSV - 2感染的人群中仅略有增加。
在这个性活跃队列中，尽管伴侣更换的总体水平有所下降，但HSV - 2血清阳性率仍急剧上升。21岁之后HSV - 2感染率增加可能是由于在生命的第三个十年中遇到的潜在伴侣中感染患病率较高。与伴侣选择相关的因素可能比单纯性伴侣数量对HSV - 2感染风险的影响更大。
