PTEN、BAX和IGFIIR基因在子宫内膜非典型增生中发生突变。
The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.
作者信息
Yoshinaga K, Sasano H, Furukawa T, Yamakawa H, Yuki M, Sato S, Yajima A, Horii A
机构信息
Department of Molecular Pathology, Tohoku University School of Medicine, Sendai.
出版信息
Jpn J Cancer Res. 1998 Oct;89(10):985-90. doi: 10.1111/j.1349-7006.1998.tb00485.x.
To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability, mutations in the PTEN, TGF beta RII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX, and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX, and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC.
为了探究子宫内膜癌发生的发病机制，我们研究了18例疑似子宫内膜癌前病变（11例子宫内膜不典型增生（ATH）、2例复杂性增生和5例单纯性增生）以及8例子宫内膜癌（EC）中的微卫星不稳定性、PTEN、TGFβRII、IGFIIR和BAX基因的突变，以及10号染色体上的杂合性缺失（LOH）。在ATH病例中，观察到10号染色体上的微卫星不稳定性（MSI）和杂合性缺失（LOH）的频率与EC中的频率相似。仅在ATH和EC中观察到PTEN、BAX和IGFIIR的突变。这些结果表明：（1）PTEN、BAX和IGFIIR在ATH中已经发生突变；（2）ATH是可能导致EC的前体病变之一。
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