Rozé C, Vaille C, Souchard M, De la Tour J, Debray C
Arch Int Pharmacodyn Ther. 1976 Jul;222(1):166-76.
The regenerating rat liver after partial hepatectomy was used as a model to study the effects of an hypolipidaemic drugs, tiadenol (bis hydroxyethylthio 1--10 decane). Seven days after partial hepatectomy, liver weight, DNA, RNA, total protein and cytochrome P-450 were increased in tiadenol treated rats, relative to hepatectomized controls. Tiadenol displaying similar effects on the intact liver, it is concluded that this hypolipidaemic drug maintains its hepatomegalic action on the regenerating rat liver.
以部分肝切除术后再生的大鼠肝脏作为模型，研究降血脂药物替阿地诺（双羟乙基硫代-1-癸烷）的作用。部分肝切除术后7天，与肝切除对照组相比，接受替阿地诺治疗的大鼠肝脏重量、DNA、RNA、总蛋白和细胞色素P-450均增加。由于替阿地诺对完整肝脏也显示出类似作用，得出结论：这种降血脂药物对再生的大鼠肝脏保持其肝肿大作用。
