Shi Y D, Artmann G, Agosti R, Longhini E
Department of Biophysics, Shanghai Medical University, China.
Clin Hemorheol Microcirc. 1998 Oct;19(2):115-27.
A modified Casson equation was established, verified satisficatorily for real conditions and suggested for use in clinical hemorheology. It provides 5 Casson parameters, i.e., Casson yield stress, Casson viscosity, the first critical point of shear rate to cause rouleaux to be broken down into smaller units, the second critical point of shear rate to completely disaggregate into individual erythrocytes, the difference between the two critical points, and also gives two series of the 5 above-mentioned Casson parameters, respectively, under original hematocrit and the standardized hematocrit of 45%. This equation not only reveals the apparent abnormalities of hypertensive patients and normalities of the healthy persons, but also reveals hidden abnormalities for patients with either low or high hematocrit. For 20 cases of hypertensive patients with low hematocrit, the 5 Casson parameters have lower values than control, but the modified equation reveals their hidden higher values than control when their hematocrit is standardized to 45%. For 7 cases of polycythemia complicated with hypertension, the 5 Casson parameters are higher at their original hematocrit, and the modified equation reveals the higher parameters than control also when the hematocrit is standardized to 45%. For 8 cases of polycythemia without complications, the 5 Casson parameters are higher at their original hematocrit than control, while the modified equation still reveals their normalities when standardizing their hematocrit to 45%.
建立了一个修正的卡森方程，该方程在实际条件下得到了满意的验证，并建议用于临床血液流变学。它提供了5个卡森参数，即卡森屈服应力、卡森粘度、使红细胞聚集体分解为较小单元的剪切速率的第一个临界点、使红细胞完全解聚为单个红细胞的剪切速率的第二个临界点、这两个临界点之间的差值，并且还分别给出了原始血细胞比容和标准化血细胞比容为45%时上述5个卡森参数的两个系列。该方程不仅揭示了高血压患者的明显异常和健康人的正常情况，还揭示了血细胞比容低或高的患者的隐藏异常。对于20例血细胞比容低的高血压患者，5个卡森参数的值低于对照组，但修正方程显示，当他们的血细胞比容标准化为45%时，其隐藏值高于对照组。对于7例高血压合并红细胞增多症患者，5个卡森参数在其原始血细胞比容时较高，当血细胞比容标准化为45%时，修正方程也显示其参数高于对照组。对于8例无并发症的红细胞增多症患者，5个卡森参数在其原始血细胞比容时高于对照组，而当将其血细胞比容标准化为45%时，修正方程仍显示其正常。
