Ghabrial R, Versace P, Kourt G, Lipson A, Martin F
Department of Ophthalmology, New Children's Hospital, Westmead, Australia.
J Pediatr Ophthalmol Strabismus. 1998 Nov-Dec;35(6):304-11; quiz 327-8. doi: 10.3928/0191-3913-19981101-04.
To review the clinical features and possible aetiology of all cases of Möbius' syndrome presented at the Royal Alexandra Hospital for Children in Sydney, Australia, from 1963 through 1995.
All charts of patients suffering from Möbius' syndrome were reviewed, and each patient was thoroughly assessed by a geneticist and a pediatric ophthalmologist.
Patterns of systemic and ocular clinical features became evident. Of 23 patients in the series, 10 (43%) had a history significant events in utero.
All patients suffering from Möbius' syndrome require thorough assessment by a multidisciplinary team including a geneticist or pediatrician and a pediatric ophthalmologist. Significant vascular events of pregnancy may explain some cases of fetal vascular disruption to the brainstem.
回顾1963年至1995年在澳大利亚悉尼皇家亚历山德拉儿童医院就诊的所有莫比乌斯综合征病例的临床特征及可能的病因。
查阅所有莫比乌斯综合征患者的病历，并由一名遗传学家和一名小儿眼科医生对每位患者进行全面评估。
全身和眼部临床特征模式变得明显。该系列中的23例患者中，10例（43%）有子宫内重大事件史。
所有莫比乌斯综合征患者都需要由包括遗传学家或儿科医生以及小儿眼科医生在内的多学科团队进行全面评估。孕期重大血管事件可能解释部分胎儿脑干血管中断的病例。
