Marrack P, Mitchell T, Bender J, Hildeman D, Kedl R, Teague K, Kappler J
Howard Hughes Medical Institute, National Jewish Medical and Research Center, Denver, Colorado, USA.
Immunol Rev. 1998 Oct;165:279-85. doi: 10.1111/j.1600-065x.1998.tb01245.x.
Like other cells, T cells are dependent on signals from their environment for their survival. Resting T cells are supported in vitro by cytokines such as interleukin (IL)-4, IL-6 and IL-7. The latter two cytokines are made constitutively in animals and hence might affect the lifetimes of their resting T cells. Resting T cells are also kept alive by interaction with an as yet unidentified molecule on the surface of other cells. Activated T cells are also supported in vitro by members of two families of these proteins, the IL-2 family and the interferon-alpha beta family. Members of the latter family may have effects on activated cells in vivo. Thus although both resting and activated T cells require signals to keep themselves alive, the signals are different for the two types of cells. This perhaps allows the immune response to control the numbers of activated cells during infections without compromising its pool of precursor, resting T cells.
与其他细胞一样，T细胞的存活依赖于来自其周围环境的信号。在体外，静息T细胞受到诸如白细胞介素（IL）-4、IL-6和IL-7等细胞因子的支持。后两种细胞因子在动物体内持续产生，因此可能影响其静息T细胞的寿命。静息T细胞还通过与其他细胞表面一种尚未确定的分子相互作用而存活。活化的T细胞在体外也受到这两类蛋白质家族成员的支持，即IL-2家族和αβ干扰素家族。后一家族的成员可能在体内对活化细胞产生影响。因此，尽管静息和活化的T细胞都需要信号来维持自身存活，但这两种类型细胞所需的信号不同。这或许使得免疫反应能够在不损害其前体静息T细胞库的情况下，在感染期间控制活化细胞的数量。
