Bobkov V M, Zubarik S A
Arkh Anat Gistol Embriol. 1976 Aug;71(8):71-7.
Under study was the alteration in the ultrastructure of the thyroid epithelium and endothelium of perifollicular capillaries influenced by exogenous thyrotropic hormone. The results obtained show that there is a direct relationship between the dosage of the injected thyrotopic hormone, the degree of the ultrastructural changes in the time of their appearance. It has been established that the alterations in the perifollicular capillary endothelium ultrastructure make their appearance and become maximum practically simulataneously with the alterations in the thyroid epithelium ultrastructure. The increased functional activity of the endothelium, thinner walls of capillaries and the appearnace of a greater amount of fenestrations against the background of the thyroid stimulation are likely to be factors contributing to penetration of non-hormonal iodine products (iodine tyrosines and products of incomplete hydrolysis of thyroglobulins) into the circulation, which can be observed under certain pathological conditions accompanied by increased thyrotropic stimulation--such as diffused toxic goiter and diffuse non-toxic goiter.
研究了外源性促甲状腺激素对甲状腺上皮细胞和滤泡周围毛细血管内皮超微结构的影响。所得结果表明，注射的促甲状腺激素剂量与超微结构变化程度及其出现时间之间存在直接关系。已经确定，滤泡周围毛细血管内皮超微结构的变化与甲状腺上皮超微结构的变化几乎同时出现并达到最大值。在甲状腺刺激的背景下，内皮功能活性增加、毛细血管壁变薄以及出现更多的窗孔，可能是促使非激素碘产物（碘酪氨酸和甲状腺球蛋白不完全水解产物）进入循环的因素，这在某些伴有促甲状腺刺激增加的病理状况下可以观察到，如弥漫性毒性甲状腺肿和弥漫性非毒性甲状腺肿。
