Toyoshima O, Kanou M, Kintaka N, Miyashita M, Shigematsu S, Sano J
Department of Surgery, Chigasaki Municipal Hospital, Chigasaki City, Kanagawa, Japan.
Surg Today. 1998;28(11):1196-9. doi: 10.1007/s005950050313.
We report herein a rare case of syringomatous adenoma (SA) of the nipple. Only 22 cases of SA of the nipple have been documented in the world literature, and to the best of our knowledge this is the first case to be reported in Japan. The patient was a 68-year-old woman who presented with a painful mass in the right subareolar region of over 15 years' duration. Clinical examination including needle biopsy indicated a high possibility of carcinoma; however, the final histopathological diagnosis after mastectomy proved to be SA. SA is a benign locally infiltrating neoplasm of the nipple which shares many clinicopathological features with adenoma of the nipple. Both lesions sometimes show deceptive clinicopathological findings, causing then to be easily confused with carcinomas. However, SA can be distinguished by its unique histological appearance resembling sweat duct, or syringomatous, tumors and locally infiltrating growth, which is probably responsible for its misleading clinical findings and higher rate of recurrence. Surgeons should be aware of the possibility of diagnosing this extremely rare tumor, and the appropriate treatment.
我们在此报告一例罕见的乳头汗腺腺瘤（SA）。世界文献中仅记载了22例乳头SA，据我们所知，这是日本首例报告的病例。患者为一名68岁女性，右侧乳晕下出现疼痛性肿块，病程超过15年。包括针吸活检在内的临床检查提示高度怀疑为癌；然而，乳房切除术后的最终组织病理学诊断为SA。SA是乳头的一种良性局部浸润性肿瘤，与乳头腺瘤有许多临床病理特征。这两种病变有时会呈现出具有欺骗性的临床病理表现，容易与癌混淆。然而，SA可通过其独特的组织学表现（类似汗腺导管或汗腺样肿瘤）和局部浸润性生长来鉴别，这可能是其临床误诊及复发率较高的原因。外科医生应意识到诊断这种极其罕见肿瘤的可能性及合适的治疗方法。
