Baba T, Nakajima S, Yajima Y
Department of Internal Medicine, Kitasato University School of Medicine, Japan.
Horm Metab Res. 1998 Oct;30(10):629-32. doi: 10.1055/s-2007-978947.
We studied the relationship between a Trp64Arg mutation of beta3-adrenergic receptor gene and hypertension in Japanese NIDDM patients without nephropathy.
Eighty-three Japanese NIDDM patients (46 men, 37 women, known duration of 12 [5-31], age of 55 [40-69] years, median and [range]) with normoalbuminuria and microalbuminuria were studied. The Trp64Arg mutation in the beta3-adrenergic receptor gene was determined by the PCR-RFLP method.
The frequency of the mutated allele was not greater in the hypertensive patients (18.2%, n=37) than in the normotensive (20.2%, n=46) patients. Genotypes with a mutate allele (i.e. Trp64/Arg64 + Arg64/Arg64) were observed in 23.5% in the hypertensive patients and in 35.7% in the normotensive patients, respectively. A similar finding in the allele frequency was observed when the analysis was made separately in the normoalbuminuric and microalbuminuric patients, respectively.
These results suggest that a Trp64Arg mutation in the beta3-adrenergic receptor gene is not associated with hypertension in Japanese NIDDM patients without nephropathy.
我们研究了β3-肾上腺素能受体基因的Trp64Arg突变与无肾病的日本2型糖尿病患者高血压之间的关系。
对83例无肾病的日本2型糖尿病患者（46例男性，37例女性，已知病程12[5 - 31]年，年龄55[40 - 69]岁，中位数及[范围]）进行研究，这些患者尿白蛋白正常及微量白蛋白尿。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测β3-肾上腺素能受体基因的Trp64Arg突变。
高血压患者（18.2%，n = 37）中突变等位基因的频率并不高于血压正常患者（20.2%，n = 46）。携带突变等位基因的基因型（即Trp64/Arg64 + Arg64/Arg64）在高血压患者中分别占23.5%，在血压正常患者中占35.7%。当分别对尿白蛋白正常和微量白蛋白尿患者进行分析时，在等位基因频率上观察到类似的结果。
这些结果表明，β3-肾上腺素能受体基因的Trp64Arg突变与无肾病的日本2型糖尿病患者的高血压无关。
