Hardin D S, Stratton R, Kramer J C, Reyes de la Rocha S, Govaerts K, Wilson D P
University of Texas Health Science Center, Houston 77030, USA.
Horm Metab Res. 1998 Oct;30(10):636-41. doi: 10.1055/s-2007-978949.
We undertook this study to determine if growth hormone treatment of prepubertal children with cystic fibrosis could improve their height and weight. Nine prepubertal children with cystic fibrosis were treated with human recombinant growth hormone for one year. Results obtained during this year were compared to similar measurements made for each patient for the one year prior to the treatment year. Anthropometric data including: height, height velocity, weight, weight velocity and skin fold thickness were measured at three month intervals. Pulmonary function and skeletal muscle strength were measured at three month intervals. Glucose tolerance was evaluated by HbAlc and by fasting blood glucose and insulin levels every three months. Our results demonstrate that growth hormone treatment resulted in significant improvement in height velocity and height Z scores. Weight increased in all subjects, with a significant increase in weight velocity (year prior to treatment = 1.7+/-1.0 kg/yr, treatment year = 3.8+/-1.6 kg/yr; p=0.03). Measurements of skin fold thickness suggests that lean body mass improved with growth hormone treatment. Pulmonary function improved in all but two patients, whose pulmonary function remained the same and muscle strength improved in all subjects. These results suggest that growth hormone used in prepubertal children with cystic fibrosis can improve height and weight and may improve lean body mass.
我们开展这项研究，以确定生长激素治疗对青春期前囊性纤维化患儿身高和体重的影响。9名青春期前囊性纤维化患儿接受了重组人生长激素治疗，为期一年。将这一年获得的结果与每位患者治疗前一年的类似测量结果进行比较。每隔三个月测量人体测量数据，包括：身高、身高增长速度、体重、体重增长速度和皮褶厚度。每隔三个月测量肺功能和骨骼肌力量。每三个月通过糖化血红蛋白（HbAlc）、空腹血糖和胰岛素水平评估葡萄糖耐量。我们的结果表明，生长激素治疗使身高增长速度和身高Z评分有显著改善。所有受试者体重均增加，体重增长速度显著提高（治疗前一年=1.7±1.0千克/年，治疗年=3.8±1.6千克/年；p=0.03）。皮褶厚度测量表明，生长激素治疗使瘦体重有所改善。除两名患者肺功能保持不变外，其他所有患者的肺功能均有改善，所有受试者的肌肉力量均有提高。这些结果表明，生长激素用于青春期前囊性纤维化患儿可改善身高和体重，并可能改善瘦体重。
