Hong Y, Rice T, Gagnon J, Després J P, Nadeau A, Pérusse L, Bouchard C, Leon A S, Skinner J S, Wilmore J H, Rao D C
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110-1093, USA.
J Clin Endocrinol Metab. 1998 Dec;83(12):4239-45. doi: 10.1210/jcem.83.12.5312.
Abdominal visceral fat (AVF) is an obesity-related phenotype thought to be associated with insulin resistance, diabetes mellitus, and atherosclerosis. Significant genetic influences on both AVF and insulin levels have been reported. However, information is lacking as to whether common genetic influences on AVF and insulin levels exist. AVF was assessed by computed tomography scan, and fasting insulin was measured by RIA in 512 members of 98 sedentary Caucasian families participating in the HERITAGE Family Study. Baseline data, collected before exercise training, were used in the present investigation. A bivariate familial correlation model was applied to evaluate whether there are familial influences that are common to insulin and AVF before and after adjustment for total fat mass (FM), and to assess the overall heritability of insulin and AVF. The maximal heritability for AVF, before and after adjustment for total FM, was 42% and 50%, respectively; and for insulin, it was 21%. Interestingly, 29% of the familial influences on insulin were also common to AVF, whereas 14% of the familial influences on AVF were shared by insulin. Furthermore, after AVF was adjusted for total FM, these common familial influences were increased to 48% and 20%. Genes and/or familial nongenetic factors with pleiotropic effects seem to influence both AVF and plasma insulin levels to a certain degree. Genes involved in the regulation of lipid storage and mobilization in the abdominal fat depot are potential candidates for these genetic pleiotropic effects.
腹部内脏脂肪（AVF）是一种与肥胖相关的表型，被认为与胰岛素抵抗、糖尿病和动脉粥样硬化有关。已有报道称基因对AVF和胰岛素水平均有显著影响。然而，关于AVF和胰岛素水平是否存在共同的基因影响，目前还缺乏相关信息。在参与遗产家庭研究的98个久坐不动的白种人家庭的512名成员中，通过计算机断层扫描评估AVF，并通过放射免疫分析法测量空腹胰岛素。本研究使用了运动训练前收集的基线数据。应用双变量家族相关性模型来评估在调整总脂肪量（FM）前后，胰岛素和AVF是否存在共同的家族影响，并评估胰岛素和AVF的总体遗传度。调整总FM前后，AVF的最大遗传度分别为42%和50%；胰岛素的最大遗传度为21%。有趣的是，对胰岛素的家族影响中有29%也与AVF共同存在，而对AVF的家族影响中有14%也与胰岛素共同存在。此外，在对AVF进行总FM调整后，这些共同的家族影响分别增加到48%和20%。具有多效性的基因和/或家族非遗传因素似乎在一定程度上影响AVF和血浆胰岛素水平。参与腹部脂肪库中脂质储存和动员调节的基因是这些遗传多效性效应的潜在候选基因。
