耻垢分枝杆菌的一种在二肽转运方面存在缺陷的突变体。
A mutant of Mycobacterium smegmatis defective in dipeptide transport.
作者信息
Bhatt A, Green R, Coles R, Condon M, Connell N D
机构信息
Department of Microbiology and Molecular Genetics, and Department of Surgery, UMDNJ/New Jersey Medical School, Newark, New Jersey 07103, USA.
出版信息
J Bacteriol. 1998 Dec;180(24):6773-5. doi: 10.1128/JB.180.24.6773-6775.1998.
Abstract
A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine (beta-alanyl-L-histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on beta-Ala and/or L-His were similar in the mutant and the wild type. However, the mutant showed significant impairment in the uptake of carnosine. This study is the first description of a peptide utilization mutant of a mycobacterium.
摘要
分离出一种耻垢分枝杆菌突变体，该突变体无法将二肽肌肽（β-丙氨酰-L-组氨酸）作为唯一碳源或氮源使用。该突变体和野生型的肌肽酶活性以及在β-丙氨酸和/或L-组氨酸上生长的能力相似。然而，该突变体在肌肽摄取方面表现出显著缺陷。本研究首次描述了分枝杆菌的一种肽利用突变体。
相似文献
1
A mutant of Mycobacterium smegmatis defective in dipeptide transport.耻垢分枝杆菌的一种在二肽转运方面存在缺陷的突变体。
J Bacteriol. 1998 Dec;180(24):6773-5. doi: 10.1128/JB.180.24.6773-6775.1998.
2
Salmonella typhimurium peptidase active on carnosine.对肌肽有活性的鼠伤寒沙门氏菌肽酶。
J Bacteriol. 1978 May;134(2):361-74. doi: 10.1128/jb.134.2.361-374.1978.
3
Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells.原代培养兔结膜上皮细胞中质子驱动的二肽摄取
Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2365-73.
4
Uptake and metabolism of beta-alanine and L-carnosine by rat tissues in vitro: role in nutrition.大鼠组织对β-丙氨酸和L-肌肽的体外摄取与代谢：在营养中的作用
Am J Physiol. 1976 Mar;230(3):643-51. doi: 10.1152/ajplegacy.1976.230.3.643.
5
An "enigmatic" L-carnosine (β-alanyl-L-histidine)? Cell proliferative activity as a fundamental property of a natural dipeptide inherent to traditional antioxidant, anti-aging biological activities: balancing and a hormonally correct agent, novel patented oral therapy dosage formulation for mobility, skeletal muscle power and functional performance, hypothalamic-pituitary- brain relationship in health, aging and stress studies.一种“神秘的”L-肌肽（β-丙氨酰-L-组氨酸）？作为传统抗氧化、抗衰老生物活性所固有的天然二肽的基本特性的细胞增殖活性：一种平衡且激素作用正确的物质，用于改善活动能力、骨骼肌力量和功能表现的新型专利口服治疗剂型，健康、衰老和应激研究中的下丘脑-垂体-脑关系
Recent Pat Drug Deliv Formul. 2015;9(1):1-64. doi: 10.2174/1872211309666141218145408.
6
A third dipeptide carrier system typified by l-prolyl-lhydroxyproline and independent of l-leucyl and beta-alanyl dipeptides in rat gut loops.以L-脯氨酰-L-羟脯氨酸为代表的第三种二肽载体系统，且该系统在大鼠肠袢中独立于L-亮氨酰和β-丙氨酰二肽。
Clin Exp Pharmacol Physiol. 1976 Nov-Dec;3(6):511-21. doi: 10.1111/j.1440-1681.1976.tb00632.x.
7
Characterization of two carnosine-degrading enzymes from rat brain. Partial purification and characterization of a carnosinase and a beta-alanyl-arginine hydrolase.大鼠脑中两种肌肽降解酶的特性研究。一种肌肽酶和一种β-丙氨酰精氨酸水解酶的部分纯化及特性分析。
Eur J Biochem. 1986 Nov 3;160(3):605-13. doi: 10.1111/j.1432-1033.1986.tb10081.x.
8
A Novel Calcium Uptake Transporter of Uncharacterized P-Type ATPase Family Supplies Calcium for Cell Surface Integrity in .一种新型未知 P 型 ATP 酶家族的钙摄取转运蛋白为 细胞表面完整性提供钙。
mBio. 2017 Sep 26;8(5):e01388-17. doi: 10.1128/mBio.01388-17.
9
Net release or uptake of histidine and carnosine in kidney of dogs.
Am J Physiol. 1985 Jan;248(1 Pt 1):E51-7. doi: 10.1152/ajpendo.1985.248.1.E51.
10
Impairment of jejunal absorption rate of carnosine by glycylglycine in man in vivo.在人体中，甘氨酰甘氨酸对肌肽空肠吸收速率的损害作用（体内实验）
Gut. 1976 Apr;17(4):252-7. doi: 10.1136/gut.17.4.252.
引用本文的文献
1
Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it.致病细菌、真菌和原生动物获取磷脂代谢物肌醇的策略：自身合成与摄取。
Microbiology (Reading). 2009 May;155(Pt 5):1386-1396. doi: 10.1099/mic.0.025718-0. Epub 2009 Apr 21.
2
Amino acid transport and metabolism in mycobacteria: cloning, interruption, and characterization of an L-Arginine/gamma-aminobutyric acid permease in Mycobacterium bovis BCG.分枝杆菌中的氨基酸转运与代谢：牛分枝杆菌卡介苗中一种L-精氨酸/γ-氨基丁酸通透酶的克隆、中断及特性分析
J Bacteriol. 2000 Feb;182(4):919-27. doi: 10.1128/JB.182.4.919-927.2000.
3
A peptide permease mutant of Mycobacterium bovis BCG resistant to the toxic peptides glutathione and S-nitrosoglutathione.一种对毒性肽谷胱甘肽和S-亚硝基谷胱甘肽具有抗性的牛分枝杆菌卡介苗肽通透酶突变体。
Infect Immun. 2000 Feb;68(2):429-36. doi: 10.1128/IAI.68.2.429-436.2000.
本文引用的文献
1
Mycobacterium: isolation, maintenance, transformation, and mutant selection.
Methods Cell Biol. 1994;45:107-25. doi: 10.1016/s0091-679x(08)61848-8.
2
Cloning and nucleotide sequence analysis of pepV, a carnosinase gene from Lactobacillus delbrueckii subsp. lactis DSM 7290, and partial characterization of the enzyme.
Microbiology (Reading). 1994 Oct;140 ( Pt 10):2591-600. doi: 10.1099/00221287-140-10-2591.
3
Beta-alanine synthesis in Escherichia coli.大肠杆菌中的β-丙氨酸合成
J Bacteriol. 1980 Mar;141(3):1291-7. doi: 10.1128/jb.141.3.1291-1297.1980.
4
2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis.2-酮戊二酸与枯草芽孢杆菌中乌头酸酶和组氨酸酶形成的调节
J Bacteriol. 1984 Apr;158(1):379-82. doi: 10.1128/jb.158.1.379-382.1984.
5
Induction and repression of the histidine-degrading enzymes in Aerobacter aerogenes.产气气杆菌中组氨酸降解酶的诱导与阻遏
J Biol Chem. 1965 Nov;240(11):4320-4.
6
Genetic basis of histidine degradation in Bacillus subtilis.枯草芽孢杆菌中组氨酸降解的遗传基础。
J Biol Chem. 1970 Jul 25;245(14):3545-8.
7
Turbidity measurements of bacterial cultures in some available commercial instruments.使用一些现有的商用仪器对细菌培养物进行浊度测量。
Anal Biochem. 1970 Nov;38(1):252-9. doi: 10.1016/0003-2697(70)90174-0.
8
Genetic control of histidine degradation in Salmonella typhimurium, strain LT-2.鼠伤寒沙门氏菌LT-2菌株中组氨酸降解的遗传控制。
J Biol Chem. 1969 Oct 10;244(19):5382-91.
9
Characterization of aminopeptidase and one dipeptidase of cytoplasmic soluble fraction from Mycobacterium phlei.
J Biochem. 1974 Jan;75(1):185-8. doi: 10.1093/oxfordjournals.jbchem.a130373.
10
Purification and characterization of an intracellular dipeptidase from Mycobacterium phlei.
Eur J Biochem. 1972 Jul 24;28(3):327-33. doi: 10.1111/j.1432-1033.1972.tb01917.x.
Zotero 插件