Kurosaki T
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570, Japan.
Int J Mol Med. 1998 Mar;1(3):515-27. doi: 10.3892/ijmm.1.3.515.
In B lymphocytes, signaling through the B cell antigen receptor (BCR) contributes to cell fate decisions with different extents of receptor engagement leading to such outcomes as cell death, survival, or proliferation. During the past several years we have seen significant strides in our understanding of the signaling pathways that connect the BCR to the nucleus. Stimulation of the BCR leads to the activation of three types of intracellular protein tyrosine kinases Lyn, Syk, and Btk. Concerted action of these tyrosine kinases leads to the phosphorylation of multiple substrates and to activation of a variety of signaling pathways including phospholipase C-gamma, Ras, and phosphatidylinositol 3-kinase activation. The ability of B lymphocytes to react appropriately to a wide variety of environment stimuli requires a high degree of regulation on these multiple signaling pathways.
在B淋巴细胞中，通过B细胞抗原受体（BCR）进行的信号传导有助于细胞命运的决定，不同程度的受体结合会导致细胞死亡、存活或增殖等结果。在过去几年中，我们对连接BCR与细胞核的信号通路的理解取得了重大进展。BCR的刺激会导致三种类型的细胞内蛋白酪氨酸激酶Lyn、Syk和Btk的激活。这些酪氨酸激酶的协同作用导致多种底物的磷酸化，并激活包括磷脂酶C-γ、Ras和磷脂酰肌醇3-激酶激活在内的多种信号通路。B淋巴细胞对多种环境刺激做出适当反应的能力需要对这些多种信号通路进行高度调节。
