Reifen R, Nyska A, Koperstein L, Zusman I
The School of Nutritional Sciences, The Hebrew University, Rehovot 67100, Israel.
Int J Mol Med. 1998 Mar;1(3):579-82. doi: 10.3892/ijmm.1.3.579.
Changes in tissue histopathology, cell morphology and kinetics and the number of mucus secreting cells were evaluated in the duodenum and colon of normal and vitamin-A-deficient rats. A lower number of goblet cells was detected both in the colon and in the duodenum of vitamin-A-deficient rats in comparison with control rats (p<0.05). vitamin-A deficiency was found to increase the proliferate rate of mucous cells in the duodenum significantly. No significant difference was noted in the proliferate index in the colon specimens in either control group of experimental rats. We suggest that the higher number of proliferating cells in the duodenal crypt and villi in the vitamin-A-deficient animals indicates that vitamin-A deficiency affects the cell proliferation and therefore could be of some importance in understanding the potency of retinoids in differentiation and their association with formation of epithelial metaplasia.
在正常和维生素A缺乏的大鼠的十二指肠和结肠中，评估了组织组织病理学、细胞形态和动力学以及黏液分泌细胞数量的变化。与对照大鼠相比，维生素A缺乏的大鼠结肠和十二指肠中的杯状细胞数量均较低（p<0.05）。发现维生素A缺乏会显著提高十二指肠中黏液细胞的增殖率。在实验大鼠的对照组中，结肠标本的增殖指数均未观察到显著差异。我们认为，维生素A缺乏动物十二指肠隐窝和绒毛中增殖细胞数量较多，表明维生素A缺乏会影响细胞增殖，因此对于理解类视黄醇在分化中的作用及其与上皮化生形成的关联可能具有一定重要性。
