Narin N, Cetin N, Kiliç H, Başbuğ M, Narin F, Kafali M, Uzüm K, Genç E, Ustünbaş H B
Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
Biol Neonate. 1999;75(2):137-42. doi: 10.1159/000014089.
The measurement of myocardial damage by newer, highly specific markers of myocardial damage is now possible, including cardiac structural proteins such as troponin T (TnT). In neonates of pre-eclamptic mothers, it identifies minor myocardial damage missed by other biochemical markers. The present study was designed to determine the diagnostic value of TnT concentrations in neonates of pre-eclamptic mothers. Fifteen neonates of pre-eclamptic mothers were studied (9 boys and 6 girls), and 17 healthy full-term neonates (9 boys and 8 girls) were selected as a control group. The serum TnT concentration in neonates of pre-eclamptic mothers (0.70 ng/ml) was significantly higher than that in the control group (0.10 ng/ml). In an echocardiographic study, the mean mitral peak velocity at an atrial contraction (A) value of 39 cm/s in neonates of pre-eclamptic mothers was significantly lower than that in the control group (53 cm/s), and the mean mitral peak velocity of early diastole to peak velocity of the atrial contraction (E/A) value (1.75) in neonates of pre-eclamptic mothers was significantly higher than that in the control subjects (1.23). In conclusion, our study demonstrated high levels of cardiac TnT, lower mitral A values and high mitral E/A values in neonates of pre-eclamptic mothers, presumably associated with mild myocardial damage in the neonates of pre-eclamptic mothers.
现在可以通过更新的、高度特异性的心肌损伤标志物来测量心肌损伤，包括心肌结构蛋白，如肌钙蛋白T（TnT）。在子痫前期母亲的新生儿中，它能识别出其他生化标志物遗漏的轻微心肌损伤。本研究旨在确定子痫前期母亲新生儿中TnT浓度的诊断价值。研究了15名单纯收缩期高血压母亲的新生儿（9名男孩和6名女孩），并选择17名健康足月儿（9名男孩和8名女孩）作为对照组。子痫前期母亲新生儿的血清TnT浓度（0.70纳克/毫升）显著高于对照组（0.10纳克/毫升）。在一项超声心动图研究中，子痫前期母亲新生儿心房收缩时二尖瓣平均峰值速度（A）值为39厘米/秒，显著低于对照组（53厘米/秒），子痫前期母亲新生儿舒张早期二尖瓣平均峰值速度与心房收缩峰值速度之比（E/A）值（1.75）显著高于对照组（1.23）。总之，我们的研究表明，子痫前期母亲的新生儿心脏TnT水平较高，二尖瓣A值较低，二尖瓣E/A值较高，这可能与子痫前期母亲的新生儿轻度心肌损伤有关。
