Narin Nazmi, Narin Figen, Tutus Ahmet, Tayyar Mehmet
Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
Pediatr Int. 2002 Apr;44(2):131-3. doi: 10.1046/j.1328-8067.2001.01522.x.
Endothelin (ET), a vasoactive mediator, like others which originate from the endothelium or circulating cells, may participate in myocardial injury. In full-term neonates of mild pre-eclamptic mothers (NMPM), it identifies minor myocardial damage missed by other biochemical markers. The present study was designed to determine the diagnostic value of ET concentrations in NMPM.
Seventeen NMPM were studied (10 boys and seven girls), and 17 healthy full-term (nine boys and eight girls) were selected for a control group. Birthweights in NMPM and control group were 2950 g (2.300-3.850) and 3.350 g (2.650-4.000), respectively. The ET measured by the radioimmunoassay method, Troponin T (TnT) were measured by enzyme-linked immunosorbent assay method and creatine kinase (CK-MB) determined in chemical 1 analysis.
Serum ET and TnT concentrations in NMPM (3.32 pg/mL vs 0.74 ng/mL) were significantly higher than the control group (0.82 pg/mL vs 0.10 ng/mL) (P < 0.01 and < 0.001).
Our study demonstrated high levels of ET, cardiac TnT in NMPM, presumably associated with myocardial damage in NMPM.
内皮素（ET）作为一种血管活性介质，与其他源自内皮或循环细胞的介质一样，可能参与心肌损伤。在轻度子痫前期母亲的足月新生儿（NMPM）中，它能识别出其他生化标志物遗漏的轻微心肌损伤。本研究旨在确定ET浓度在NMPM中的诊断价值。
研究了17例NMPM（10例男孩和7例女孩），并选择17例健康足月儿（9例男孩和8例女孩）作为对照组。NMPM组和对照组的出生体重分别为2950 g（2.300 - 3.850）和3350 g（2.650 - 4.000）。采用放射免疫分析法测定ET，采用酶联免疫吸附测定法测定肌钙蛋白T（TnT），并通过化学分析法测定肌酸激酶（CK-MB）。
NMPM组的血清ET和TnT浓度（3.32 pg/mL对0.74 ng/mL）显著高于对照组（0.82 pg/mL对0.10 ng/mL）（P < 0.01和< 0.001）。
我们的研究表明，NMPM中ET和心脏TnT水平较高，推测与NMPM中的心肌损伤有关。
