人孕激素受体（PGR）基因座上多态性CA重复序列的分离。

Isolation of a polymorphic CA repeat sequence at the human progesterone receptor (PGR) locus.

作者信息

Tsukamoto K, Watanabe I, Shiba T, Emi M

机构信息

Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan.

出版信息

J Hum Genet. 1998;43(4):287-8. doi: 10.1007/s100380050094.

DOI:10.1007/s100380050094

PMID:9852688

Abstract

We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the human progesterone receptor (PGR) gene. This polymorphism will be a useful marker in the genetic study of disorders affecting female endocrine systems, such as progesterone resistance and breast, uterine, and ovarian cancers.

摘要

我们从一个包含人孕激素受体（PGR）基因的基因组克隆中分离出一个多态性二核苷酸（CA）重复序列。这种多态性将成为影响女性内分泌系统疾病（如孕激素抵抗以及乳腺癌、子宫癌和卵巢癌）遗传研究中的一个有用标记。