Hashimoto I, Miyamura M, Saito M
Laboratory of Applied Physiology, Toyota Technological Institute, Nagoya, Japan.
Acta Physiol Scand. 1998 Nov;164(3):293-7. doi: 10.1046/j.1365-201X.1998.00437.x.
To investigate the effects of maximal voluntary exercise on sympathetic nerve activity, contraction force and muscle sympathetic nerve activity (MSNA) were recorded during maximal (MVG) and submaximal voluntary isometric handgrip (SVG) for 2 min in eight healthy subjects. MSNA was determined by a microneurographic technique, and handgrip force, heart rate (HR) and arterial blood pressure (ABP) were measured by a non-invasive method during exercise. Grip force decayed rapidly to 58% of maximal grip force (MGF) at 10 s after commencement of exercise and was almost constant (approximately 30% of MGF) 40 s after exercise. MSNA increase was delayed by 20 s during MVG, followed by a gradual increase. HR was elevated immediately after onset of exercise, while mean ABP rise showed a 20 s lag from initiation of MVG exercise. During SVG increases in MSNA, HR and mean ABP were delayed by 50, 40 and 20 s, respectively, relative to commencement of exercise. Thereafter, these parameters increased time-dependently. These results suggested that the MSNA increase during MVG may be predominantly because of the metaboreflex.
为研究最大自主运动对交感神经活动的影响，对8名健康受试者进行了2分钟的最大自主等长握力（MVG）和次最大自主等长握力（SVG）试验，期间记录收缩力和肌肉交感神经活动（MSNA）。MSNA通过微神经电图技术测定，运动期间通过非侵入性方法测量握力、心率（HR）和动脉血压（ABP）。运动开始后10秒，握力迅速衰减至最大握力（MGF）的58%，运动40秒后几乎保持恒定（约为MGF的30%）。MVG期间，MSNA的增加延迟了20秒，随后逐渐增加。运动开始后心率立即升高，而平均ABP升高在MVG运动开始后有20秒的延迟。在SVG期间，MSNA、HR和平均ABP的增加相对于运动开始分别延迟了50、40和20秒。此后，这些参数随时间增加。这些结果表明，MVG期间MSNA的增加可能主要是由于代谢反射。
