Magariños A M, Orchinik M, McEwen B S
Department of Biology, Arizona State University, Tempe, USA.
Brain Res. 1998 Nov 2;809(2):314-8. doi: 10.1016/s0006-8993(98)00882-8.
Repeated stress induces atrophy, or remodeling, of apical dendrites in hippocampal CA3 pyramidal neurons. In rats, the stress effect is blocked by adrenal steroid synthesis inhibitors, and mimicked by daily injection of corticosterone. We report that non-invasive administration of corticosterone in the drinking water (400 micrograms/ml) also produced atrophy of apical dendrites in CA3. Unexpectedly, the combination of daily stress and oral corticosterone negated the effects of either treatment alone, and no changes in the apical dendritic length or branching pattern of CA3 pyramidal neurons were observed compared to control unstressed rats.
反复应激会导致海马CA3区锥体神经元顶树突萎缩或重塑。在大鼠中，应激效应可被肾上腺类固醇合成抑制剂阻断，并可通过每日注射皮质酮来模拟。我们报告称，通过饮用水（400微克/毫升）非侵入性给予皮质酮也会导致CA3区顶树突萎缩。出乎意料的是，每日应激与口服皮质酮的联合作用抵消了单独任何一种治疗的效果，与未受应激的对照大鼠相比，未观察到CA3区锥体神经元顶树突长度或分支模式的变化。
