Arbab A S, Koizumi K, Toyama K, Arai T, Yoshitomi T, Araki T
Department of Radiology, Yamanashi Medical University, Japan.
Nucl Med Commun. 1998 May;19(5):411-6. doi: 10.1097/00006231-199805000-00002.
The aim of this study was to characterize lung lesions by means of the uptake, retention and washout of 201Tl, and to quantify the sensitivity of 201Tl SPET (single photon emission tomography) in detecting mediastinal and hilar lymph nodes. A total of 68 patients with lung lesions (tumours and inflammation) underwent both helical computed tomography (CT) and 201Tl SPET examinations. Uptake, retention and washout parameters were calculated from early and delayed 201Tl SPET by drawing regions of interest over the primary lesion and the background of the lung. The findings on 201Tl SPET were compared with those on CT and surgical findings. A significant difference in the retention index (RI) was observed between primary malignant and benign lesions. In detecting lymph nodes, the sensitivity, specificity and negative predictive value were 83%, 60% and 90% respectively for early 201Tl SPET, and 50%, 80% and 80% respectively for delayed 201Tl SPET. 201Tl SPET with semi-quantitative analysis, especially RI, helps to differentiate between malignant and benign lung lesions. Lymph nodes larger than 1 cm on CT but not showing 201Tl uptake could be considered non-metastatic lesions.
本研究的目的是通过铊-201的摄取、滞留和洗脱来描述肺部病变的特征，并量化铊-201单光子发射断层扫描（SPET）检测纵隔和肺门淋巴结的敏感性。共有68例肺部病变（肿瘤和炎症）患者接受了螺旋计算机断层扫描（CT）和铊-201 SPET检查。通过在原发灶和肺部背景上绘制感兴趣区域，从早期和延迟的铊-201 SPET计算摄取、滞留和洗脱参数。将铊-201 SPET的结果与CT和手术结果进行比较。在原发性恶性病变和良性病变之间观察到滞留指数（RI）存在显著差异。在检测淋巴结方面，早期铊-201 SPET的敏感性、特异性和阴性预测值分别为83%、60%和90%，延迟铊-201 SPET的敏感性、特异性和阴性预测值分别为50%、80%和80%。进行半定量分析的铊-201 SPET，尤其是RI，有助于区分恶性和良性肺部病变。CT上大于1 cm但未显示铊-201摄取的淋巴结可被视为非转移性病变。
