Arbab A S, Koizumi K, Toyama K, Arai T, Araki T
Department of Radiology, Yamanashi Medical University, Japan.
Nucl Med Commun. 1998 Jul;19(7):657-63. doi: 10.1097/00006231-199807000-00007.
The aim of this study was to assess the usefulness of 99Tcm-tetrofosmin for detecting tumours of the lungs and adjacent structures and to compare the results with those for 201Tl. In the 18 patients studied, there were 30 lesions in total. Dual-isotope SPET acquisitions were performed 10 min and 3 h after the administration of 99Tcm-tetrofosmin and 201Tl. Image quality and semi-quantitative parameters were evaluated for both tracers. All lesions were detected by the two radiopharmaceuticals on both the early and delayed images. In seven patients, the image quality of 99Tcm-tetrofosmin was better than that of 201Tl. For the detection of metastatic lymph nodes, the delayed 201Tl and the early 99Tcm-tetrofosmin images were superior. No significant difference was observed between the uptake ratios of the two tracers. 99Tcm-tetrofosmin showed significantly (P < 0.001) higher washout than 201Tl from both the lesions and normal lungs, although washout of 201Tl from normal lungs was significantly higher than that from the lesions. In conclusion, 99Tcm-tetrofosmin may be helpful for detecting tumours of the lungs and adjacent structures, but has limited applicability in differentiating between malignant and benign tumours and may not be used instead of 201Tl to detect malignant tumours of the lungs.
本研究的目的是评估99锝-替曲膦用于检测肺部及邻近结构肿瘤的有效性，并将结果与201铊的结果进行比较。在研究的18例患者中，共有30个病灶。在注射99锝-替曲膦和201铊后10分钟和3小时进行双同位素单光子发射计算机断层扫描（SPET）采集。对两种示踪剂的图像质量和半定量参数进行了评估。两种放射性药物在早期和延迟图像上均检测到了所有病灶。在7例患者中，99锝-替曲膦的图像质量优于201铊。对于转移性淋巴结的检测，延迟的201铊图像和早期的99锝-替曲膦图像更具优势。两种示踪剂的摄取率之间未观察到显著差异。99锝-替曲膦从病灶和正常肺组织中的洗脱均显著高于201铊（P < 0.001），尽管201铊从正常肺组织中的洗脱显著高于从病灶中的洗脱。总之，99锝-替曲膦可能有助于检测肺部及邻近结构的肿瘤，但在鉴别恶性和良性肿瘤方面适用性有限，可能不能替代201铊用于检测肺部恶性肿瘤。
