Rabbolini S, Verardo E, Da Col M, Gioacchini A M, Traldi P
RIBBON S.r.l., Milano, Italy.
Rapid Commun Mass Spectrom. 1998;12(22):1820-6. doi: 10.1002/(SICI)1097-0231(19981130)12:22<1820::AID-RCM387>3.0.CO;2-C.
The mass spectrometry (MS) behaviour of ten commercially available penicillins has been studied by means of electrospray and multiple-stage MS/MS experiments performed using an ion trap instrument. For all the examined compounds negative ions are produced under ESI conditions, with a yield two or three orders of magnitude higher than that observed for positive ions. MSn experiments indicate the occurrence of a fragmentation pathway related to the beta-lactam ring, different from that usually described for positive ions of these compounds, and provide structural information on both the beta-lactam ring and the side chains.
利用离子阱仪器进行电喷雾和多级MS/MS实验，研究了十种市售青霉素的质谱（MS）行为。在电喷雾电离（ESI）条件下，所有检测的化合物均产生负离子，其产率比正离子高两到三个数量级。串联质谱（MSn）实验表明，存在一种与β-内酰胺环相关的裂解途径，这与通常描述的这些化合物正离子的裂解途径不同，并提供了有关β-内酰胺环和侧链的结构信息。
