Ikarashi F
Department of Otolaryngology, The Nippon Dental University School of Dentistry at Niigata, Japan.
Auris Nasus Larynx. 1998 Dec;25(4):349-54. doi: 10.1016/s0385-8146(98)00011-x.
The purpose of this study was to examine the effect of respiratory mode on the human middle ear pressure. The partial pressure of carbon dioxide in the venous blood (PvCO2) and the middle ear pressure were increased by hypoventilation, and decreased by hyperventilation. The partial pressure of oxygen in the venous blood showed little change. It was considered that CO2 diffused into the middle ear cleft according to the partial pressure gradient when the PvCO2 was elevated by hypoventilation, resulting in increase of the middle ear pressure, whereas CO2 diffused into the blood from the middle ear cleft when the PvCO2 was reduced by hyperventilation, resulting in decrease of the middle ear pressure. These findings suggest that bidirectional gas exchange via the middle ear mucosa functions actively in the human middle ear and plays an essential role in the regulation of the middle ear pressure.
本研究的目的是探讨呼吸模式对人中耳压力的影响。静脉血中二氧化碳分压（PvCO2）和中耳压力通过通气不足而升高，通过过度通气而降低。静脉血中的氧分压变化不大。据认为，当通气不足使PvCO2升高时，CO2根据分压梯度扩散到中耳腔隙，导致中耳压力升高，而当过度通气使PvCO2降低时，CO2从中耳腔隙扩散到血液中，导致中耳压力降低。这些发现表明，通过中耳黏膜的双向气体交换在人中耳中发挥着积极作用，并且在中耳压力调节中起着至关重要的作用。
