Traversa G, Spila-Alegiani S, Arpino C, Ferrara M
Department of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Rome, Italy.
J Child Adolesc Psychopharmacol. 1998;8(3):175-80. doi: 10.1089/cap.1998.8.175.
The objective of this study was to describe the use of neuroleptics among children and adolescents in the province of Rome. Subjects 5 to 19 years of age who received neuroleptic prescriptions within the National Health Service between 1986 and 1991 were identified. Prevalence and incidence of use were estimated. The yearly prevalence of use during the study period ranged from 1.3 to 1.7 per 1000 inhabitants. The incidence during 1989 was 1.1 per 1000, with a marked increase with age. Haloperidol was the drug most frequently prescribed; 59.2% of the subjects received only one prescription during the year. Among subjects with more than one prescription, 42.3% received neuroleptics in combination. The observed pattern of use suggests that in current practice neuroleptics are also used for the treatment of nonpsychotic conditions. The analysis of data derived from a prescription monitoring system may provide an important contribution to the description of neuroleptic use among children and adolescents.
本研究的目的是描述罗马省儿童和青少年中抗精神病药物的使用情况。确定了1986年至1991年期间在国家医疗服务体系内接受抗精神病药物处方的5至19岁受试者。估计了药物使用的患病率和发病率。研究期间每年的使用患病率为每1000名居民1.3至1.7例。1989年的发病率为每1000人1.1例,且随年龄显著增加。氟哌啶醇是最常开具的药物;59.2%的受试者在该年度仅接受了一张处方。在接受多张处方的受试者中,42.3%联合使用了抗精神病药物。观察到的使用模式表明,在当前实践中,抗精神病药物也用于治疗非精神病性疾病。对来自处方监测系统的数据进行分析可能会为描述儿童和青少年抗精神病药物的使用情况做出重要贡献。