Beshay H, Pumariega A J
James H. Quillen College of Medicine, East Tennessee State University, Quillen/Mountain Home Veterans Administration Medical Center, Johnson City 37684, USA.
J Child Adolesc Psychopharmacol. 1998;8(3):187-93. doi: 10.1089/cap.1998.8.187.
The use of corticosteroids, particularly high-potency steroids, for the treatment of various inflammatory conditions has been frequently associated with mood disturbance and psychosis. We report on a 12-year-old white boy treated with high doses of prednisone chronically for 7 years who presented with severe depression, irritability, violence, and psychosis. Sertraline was used to treat depressive as well as psychotic symptoms without the use of antipsychotics. This successful treatment of steroid-induced mood disorder and psychosis with a serotonin reuptake inhibitor is consistent with the literature describing a decrease in central and peripheral serotonin secretion due to steroids, as well as a possible relationship between mood and psychotic symptoms and low cerebrospinal fluid serotonin levels.
使用皮质类固醇，尤其是高效能类固醇来治疗各种炎症性疾病，常常与情绪障碍和精神病相关。我们报告了一名12岁白人男孩，他长期大剂量服用泼尼松7年，出现了严重的抑郁、易怒、暴力和精神病症状。使用舍曲林治疗抑郁和精神病症状，未使用抗精神病药物。用5-羟色胺再摄取抑制剂成功治疗类固醇诱导的情绪障碍和精神病，这与文献报道一致，即类固醇会导致中枢和外周5-羟色胺分泌减少，以及情绪和精神病症状与脑脊液中低5-羟色胺水平之间可能存在关联。
