Mager M, Robinson S, Freinkel N
J Appl Physiol. 1976 Oct;41(4):559-64. doi: 10.1152/jappl.1976.41.4.559.
2-Deoxy-D-glucose (2-DG), insulin, or norepinephrine (NE), when injected into the cerebral ventricles of conscious mice, produce decreased rates of O2 consumption and hypothermia. These changes are accompanied by hyperglycemia with 2-DG, hypoglycemia with insulin, and normoglycemia with NE. Desipramine blocks the reduction in body temperature and O2 consumption produced by each of these agents, but does not modify significantly their effects on plasma glucose. The latter suggests that the thermal and oxidative responses to central glucopenia can be dissociated from concurrent alterations in circulating glucose. Propranolol enhances the hypothermic response produced by administered 2-DG, insulin, or NE. Phentolamine, however, antagonizes the hypothermia only with NE, indicating the 2-DG and insulin are probably not acting through the release of endogenous NE.
将2-脱氧-D-葡萄糖（2-DG）、胰岛素或去甲肾上腺素（NE）注射到清醒小鼠的脑室中时，会导致耗氧率降低和体温过低。这些变化伴随着2-DG引起的高血糖、胰岛素引起的低血糖以及NE引起的血糖正常。地昔帕明可阻断这些药物各自引起的体温降低和耗氧减少，但对它们对血浆葡萄糖的影响没有显著改变。后者表明，对中枢性低血糖的热反应和氧化反应可以与循环葡萄糖的同时变化相分离。普萘洛尔会增强给予2-DG、胰岛素或NE所产生的体温过低反应。然而，酚妥拉明仅能拮抗NE引起的体温过低，这表明2-DG和胰岛素可能不是通过释放内源性NE起作用的。
