Francesconi R, Mager M
Am J Physiol. 1980 Sep;239(3):R214-8. doi: 10.1152/ajpregu.1980.239.3.R214.
Adult male mice were administered several doses of 5-thio-D-glucose (5-TG) at two environmental temperatures, 4 and 22 degrees C. Both intracerebroventricular (icv) and intraperitoneal (ip) administration of 5-TG resulted in significant (P < 0.05 to P < 0.001) decrements in rectal temperature (Tre) that were dose dependent. After 30 min, the hypothermic effects were significantly (P < 0.001, icv, 100 microgram) exacerbated by cold exposure (4 vs. 22 degrees C) and were likewise intensified significantly (P < 0.005, 45 min, fed vs. 18 h fasted) by food deprivation. These reductions in Tre were accompanied by significant (P < 0.001) increases in circulating levels of glucose. The present results indicate that 5-TG may be eliciting both central and peripheral cellular glucopenia concomitant with circulatory hyperglycemia; thus, the resultant hypothermia may be arising from competitive inhibition of glycolysis by 5-TG intermediates as well as reduced availability of tissue glucose.
成年雄性小鼠在4摄氏度和22摄氏度这两种环境温度下接受了几剂5-硫代-D-葡萄糖（5-TG）。脑室内（icv）和腹腔内（ip）注射5-TG均导致直肠温度（Tre）显著降低（P < 0.05至P < 0.001），且呈剂量依赖性。30分钟后，冷暴露（4摄氏度与22摄氏度）显著加剧了低温效应（P < 0.001，icv，100微克），禁食同样显著增强了低温效应（P < 0.005，45分钟，喂食与禁食18小时）。Tre的这些降低伴随着循环葡萄糖水平的显著升高（P < 0.001）。目前的结果表明，5-TG可能同时引发中枢和外周细胞低血糖以及循环性高血糖；因此，由此产生的体温过低可能是由于5-TG中间体对糖酵解的竞争性抑制以及组织葡萄糖可用性降低所致。
