Dormer K J, Stone H L
J Appl Physiol. 1976 Oct;41(4):574-80. doi: 10.1152/jappl.1976.41.4.574.
A fastigial pressor response has been elicited in the anesthetized mongrel dog. Stimulation within the rostral portions of this nucleus results in mean arterial pressure rises up to 150 mmHg above control. A proportional tachycardia is simultaneously evoked which may rapidly attain heart rates of 190 beats/min above control levels. Peak tachycardias immediately suside and often the heart rate declines below control values during stimulation while arterial pressure remains elevated. When either the carotid sinuses were isolated by ligation or a bilateral vagotomy was performed, the fastigial tachycardia was sustained. Thresholds for the response are near 0.05 mA and the stimulus intensity curve is linear to 0.4 mA whereupon the pressure rise and tachycardia begin to approach a plateau value. The response could still be attained when submaximal doses of alpha-chloralose anesthesia or high levels of barbiturates (30-40 mg/kg) were given. Both portions of the response result from widespread sympathetic activation; however, buffering of the response through the baroreceptor reflexes is only demonstrated in the cardiac segment of the response.
在麻醉的杂种狗身上已引发了小脑顶核升压反应。刺激该核头端部分会导致平均动脉压比对照值升高达150 mmHg。同时会诱发成比例的心动过速，其心率可能迅速升至比对照水平高190次/分钟。心动过速峰值会立即消退，且在刺激期间心率常降至对照值以下，而动脉压仍保持升高。当通过结扎隔离颈动脉窦或进行双侧迷走神经切断术时，小脑顶核性心动过速会持续。该反应的阈值接近0.05 mA，刺激强度曲线在0.4 mA之前呈线性，此后压力升高和心动过速开始接近平台值。当给予亚最大剂量的α-氯醛糖麻醉或高剂量巴比妥类药物（30 - 40 mg/kg）时，仍可获得该反应。该反应的两个部分均源于广泛的交感神经激活；然而，通过压力感受器反射对该反应的缓冲仅在反应的心脏部分得到体现。
