Dormer K J, Stone H L
J Auton Nerv Syst. 1980 Oct;2(3):269-80. doi: 10.1016/0165-1838(80)90016-8.
The fastigial nucleus pressor response (FPR) and the nasal-perfusion diving response were elicited alone and simultaneously to observe the net effect on cardiovascular variables. The fastigial nucleus was electrically stimulated in 14-chloralose-urethane anesthetized dogs and the FPR was characterized by a transient tachycardia with sustained elevations in arterial pressure, left ventricular pressure and maximal dP/dt. The tachycardia was buffered by baroreceptor reflexes during the elevated arterial pressure of the FPR. All variable of the FPR, however, were reduced by superimposition of the diving response upon the FPR. Heart rate was most sensitive to depression by the nasal perfusion which elicited a bradycardia as much as 70 beats/min below the control rate. The nasal-evoked diving response was discussed with respect to the trigeminal depressor response which results from direct stimulation of the spinal trigeminal complex. Algebraic cancellation of the FPR and dive responses is considered along with anatomical and electrophysiological evidence which suggests that these two responses, as well as the baroreceptor reflex, could be integrated at a common site. This site may be the medullary nucleus of the solitary tract which receives projections from trigeminal and glossopharyngeal nerves and from the fastigial nucleus.
单独及同时引发顶核升压反应（FPR）和鼻灌注潜水反应，以观察对心血管变量的净效应。在14-氯醛糖-乌拉坦麻醉的犬中对顶核进行电刺激，FPR的特征为短暂性心动过速，同时动脉压、左心室压和最大dP/dt持续升高。在FPR动脉压升高期间，心动过速被压力感受器反射缓冲。然而，在FPR基础上叠加潜水反应会使FPR的所有变量降低。心率对鼻灌注引起的抑制最为敏感，鼻灌注可引发心动过缓，心率比对照值低多达70次/分钟。结合由直接刺激三叉神经复合体产生的三叉神经降压反应讨论了鼻诱发的潜水反应。考虑了FPR和潜水反应的代数抵消，以及解剖学和电生理学证据，这些证据表明这两种反应以及压力感受器反射可能在一个共同部位整合。这个部位可能是孤束核，它接受来自三叉神经和舌咽神经以及顶核的投射。
