Llinás R, Ribary U, Contreras D, Pedroarena C
Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA.
Philos Trans R Soc Lond B Biol Sci. 1998 Nov 29;353(1377):1841-9. doi: 10.1098/rstb.1998.0336.
Attempting to understand how the brain, as a whole, might be organized seems, for the first time, to be a serious topic of inquiry. One aspect of its neuronal organization that seems particularly central to global function is the rich thalamocortical interconnectivity, and most particularly the reciprocal nature of the thalamocortical neuronal loop function. Moreover, the interaction between the specific and non-specific thalamic loops suggests that rather than a gate into the brain, the thalamus represents a hub from which any site in the cortex can communicate with any other such site or sites. The goal of this paper is to explore the basic assumption that large-scale, temporal coincidence of specific and non-specific thalamic activity generates the functional states that characterize human cognition.
试图理解作为一个整体的大脑是如何组织起来的，似乎首次成为一个严肃的探究主题。其神经元组织中一个似乎对整体功能特别核心的方面是丰富的丘脑皮质相互连接性，尤其是丘脑皮质神经元回路功能的相互性质。此外，特异性和非特异性丘脑回路之间的相互作用表明，丘脑并非大脑的一个入口，而是一个枢纽，皮层中的任何部位都可以通过它与任何其他这样的部位进行通信。本文的目的是探讨这样一个基本假设，即特异性和非特异性丘脑活动在时间上的大规模同步产生了表征人类认知的功能状态。
