树突状钙电导在丘脑皮质神经元中产生高频振荡。
Dendritic calcium conductances generate high-frequency oscillation in thalamocortical neurons.
作者信息
Pedroarena C, Llinás R
机构信息
Department of Physiology and Neurosciences, New York University Medical Center, New York 10016, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):724-8. doi: 10.1073/pnas.94.2.724.
Abstract
Cortical-projecting thalamic neurons, in guinea pig brain slices, display high-frequency membrane potential oscillations (20-80 Hz), when their somata are depolarized beyond -45 mV. These oscillations, preferentially located at dendritic sites, are supported by the activation of P/Q type calcium channels, as opposed to the expected persistent sodium conductance responsible for such rhythmic behavior in other central neurons. Short hyperpolarizing pulses reset the phase and transiently increase the amplitude of these oscillations. This intrinsic thalamic electroresponsiveness may serve as a cellular-based temporal binding mechanism that sharpens the temporal coincidence of cortical-feedback synaptic inputs, known to distribute at remote dendritic sites on thalamic neurons.
摘要
在豚鼠脑片中，当皮质投射丘脑神经元的胞体去极化超过-45 mV时，会表现出高频膜电位振荡（20-80 Hz）。这些振荡优先出现在树突部位，由P/Q型钙通道的激活所支持，这与其他中枢神经元中负责这种节律行为的预期持续性钠电导不同。短暂的超极化脉冲会重置振荡相位并短暂增加其幅度。这种丘脑内在的电反应性可能作为一种基于细胞的时间绑定机制，增强皮质反馈突触输入的时间一致性，已知这些输入分布在丘脑神经元的远端树突部位。
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