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两个基于人群的样本中主要精神疾病诊断的选型交配。

Assortative mating for major psychiatric diagnoses in two population-based samples.

作者信息

Maes H H, Neale M C, Kendler K S, Hewitt J K, Silberg J L, Foley D L, Meyer J M, Rutter M, Simonoff E, Pickles A, Eaves L J

机构信息

Department of Human Genetics, Virginia Commonwealth University, Richmond 23298-0003, USA.

出版信息

Psychol Med. 1998 Nov;28(6):1389-401. doi: 10.1017/s0033291798007326.

Abstract

BACKGROUND

Previous studies on assortment for psychiatric disorders have reported discrepant findings. We aimed to test whether there is a significant association for psychiatric diagnoses, including alcoholism, generalized anxiety disorder, major depressive disorder, panic disorder and phobias between husbands and wives in two population-based samples. We further evaluated whether marital resemblance occurs primarily within or across psychiatric disorders and if assortment for psychopathology is primary or secondary to assortment for correlated variables.

METHODS

A model for mate selection addressed whether the correlation between mates for psychiatric disorders arises from direct assortment (primary homogamy) or through correlation with other variables for which assortment occurs (secondary homogamy) or through cross-variable assortment. The model accounted for within-person co-morbidity as well as across-spouse data.

RESULTS

Findings suggested that a moderate degree of assortment exists both within and across psychiatric diagnoses. Only a small amount of the observed marital resemblance for mental illness could be explained by assortment for correlated variables such as age, religious attendance and education. Similar results were obtained for the two samples separately and confirmed in their joint analysis, revealing that the co-morbidity and assortment findings, except for the marital correlation for age, religious attendance and education, replicate across samples.

CONCLUSIONS

Significant but moderate primary assortment exists for psychiatric disorders. The bias in twin studies that have ignored the small amount of assortment is negligible.

摘要

背景

先前关于精神疾病分类配对的研究报告结果存在差异。我们旨在检验在两个基于人群的样本中,丈夫和妻子之间在包括酒精中毒、广泛性焦虑症、重度抑郁症、恐慌症和恐惧症等精神疾病诊断方面是否存在显著关联。我们进一步评估婚姻相似性主要是在精神疾病内部还是跨精神疾病出现,以及精神病理学的分类配对是主要的还是次要的相关变量分类配对。

方法

一个择偶模型探讨了配偶之间精神疾病的相关性是源于直接分类配对(主要同质性)还是通过与发生分类配对的其他变量的相关性(次要同质性)或通过跨变量分类配对。该模型考虑了个体内共病以及配偶间数据。

结果

研究结果表明,在精神疾病诊断内部和之间都存在一定程度的分类配对。观察到的精神疾病婚姻相似性中,只有一小部分可以通过年龄、宗教活动参与度和教育等相关变量的分类配对来解释。分别对两个样本进行分析得到了类似结果,并在联合分析中得到证实,这表明除了年龄、宗教活动参与度和教育的婚姻相关性外,共病和分类配对结果在不同样本中具有重复性。

结论

精神疾病存在显著但适度的主要分类配对。忽略少量分类配对的双生子研究中的偏差可以忽略不计。

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